Monday, 4 October 2010

a 20-year-old man with dizziness on standing

ben a presented a very interesting case of a young man in the UK for a course in political science as part of an Erasmus programme who presented to casualty with marked lightheadedness on standing of 1 days duration

we discussed (again) the issue of pinning down what a patient means by dizziness

here our patient was fine lying flat but became lightheaded with altered vision on standing

there was also associated nausea & abdominal pain

he was able to move into his flat (with the attendant box lugging) on the saturday

any ideas as to diagnosis?
_ _ _

there seems to be a clear story of postural symptoms, most likely secondary to hypovolaemia

[causes orthostatic hypotension?: diabetes, drugs, parkinsons, autonomic dysfunction, addisons]

we briefly talked about blood loss

(1 pint is actually a US pint or 473mL, not the UK (imperial) pint of 568mL)

catastrophic blood loss might occur into the gut, lungs, abdomen, pelvis

lethal bleeding (without exsanguinating) into the pericardium or brain
_ _ _

we mentioned the surface markings of the pleura but did not finish the conversation

see here for more
_ _ _

we then went to chat to our patient who has addisons disease

click here for thomas addison's own pictures (he was a physician at guys)

[NB why do people with addisons exhibit hyperpigmentation?]

JFK had addisons

our patient was first diagnosed in the US 2 months ago

he takes 20mg of hydrocortisone daily as his normal regimen (which he tripled over the weekend)
_ _ _

on examination he had no hyperpigmentation in the buccal mucosa or palmar creases

he had a 15mmHg systolic drop on admission (?now)

his abdomen was soft & non-tender with no masses or organomegaly
_ _ _

on arrival he had a Na of 120mmol/L with a K of 6.8

his ECG showed peaked T waves

he was given calcium gluconate & insulin/dextrose
_ _ _

we briefly mentioned causes of addisons disease:

autoimmune, infection (incl TB), hameorrhage, cancer, congential adrenal hyperplasia, pituitary problems

investigations:

importantly electrolytes, septic screen
_ _ _

things to read about:

1) addisons
2) emergency treatment of hyperK
3) hydrocortisone


Salaam


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